KAUST Repository :443 The KAUST Repository digital repository system captures, stores, indexes, preserves, and distributes digital research material. 2021-05-24T11:38:32Z Aortic blood pressure estimation: A hybrid machine-learning and cross-relation approach http://hdl.handle.net/10754/669209 Aortic blood pressure estimation: A hybrid machine-learning and cross-relation approach Magbool, Ahmed; Bahloul, Mohamed; Ballal, Tarig; Al-Naffouri, Tareq Y.; Laleg-Kirati, Taous-Meriem Aortic blood pressure is a vital signal that provides valuable medical information about cardiovascular health condition. Noninvasive measurement of this signal is very challenging, which motivates several researchers to develop mathematical approaches over the years to estimate the aortic pressure from peripheral measurements. Most of these approaches are limited in their performance as they fail to recover important features of the blood pressure signal. To overcome this issue, we investigate the application of machine-learning methods to estimate the aortic blood pressure from peripheral signals. In the absence of reasonably large datasets, we rely on pre-validated virtual databases to train our machine-learning models. To avoid model bias due to the lack of diversity and variability in these databases, we propose a hybrid approach that combines machine-learning models with the cross-relation blind estimation approach. On top of that, a sparse representation, coupled with a dictionary-learning approach, is employed to emphasize the characteristics of the aortic pressure signals and generate more meaningful outputs. Our results show that the proposed hybrid approach offers a reduction in the root-mean-squared error compared to pure machine-learning models and improvement compared to the cross-relation method. The proposed approach also shows a noticeable potency in capturing fine features of the aortic blood pressure signal. 2021-05-23T00:00:00Z Multi-domain probiotic consortium as an alternative to chemical remediation of oil spills at coral reefs and adjacent sites. http://hdl.handle.net/10754/669208 Multi-domain probiotic consortium as an alternative to chemical remediation of oil spills at coral reefs and adjacent sites. Silva, Denise P; Villela, Helena D M; Santos, Henrique F; Duarte, Gustavo A S; Ribeiro, Jos¨¦ Roberto; Ghizelini, Angela M; Vilela, Caren L S; Rosado, Phillipe M; Fazolato, Carolline S; Santoro, Erika P; Carmo, Flavia L; Ximenes, Dalton S; Soriano, Adriana U; Rachid, Caio T C C; Vega Thurber, Rebecca L; Peixoto, Raquel S BackgroundBeginning in the last century, coral reefs have suffered the consequences of anthropogenic activities, including oil contamination. Chemical remediation methods, such as dispersants, can cause substantial harm to corals and reduce their resilience to stressors. To evaluate the impacts of oil contamination and find potential alternative solutions to chemical dispersants, we conducted a mesocosm experiment with the fire coral Millepora alcicornis, which is sensitive to environmental changes. We exposed M. alcicornis to a realistic oil-spill scenario in which we applied an innovative multi-domain bioremediator consortium (bacteria, filamentous fungi, and yeast) and a chemical dispersant?(Corexit? 9500, one of the?most widely used dispersants), to assess the effects on host health and host-associated microbial communities.ResultsThe selected multi-domain microbial?consortium helped to mitigate the impacts of the oil, substantially degrading the polycyclic aromatic and n-alkane fractions and maintaining the physiological integrity of the corals. Exposure to Corexit 9500 negatively impacted the host physiology and altered the coral-associated microbial community. After exposure, the abundances of certain bacterial genera such as Rugeria and Roseovarius increased, as previously reported in stressed or diseased corals. We also identified several bioindicators of Corexit 9500 in the microbiome. The impact of Corexit 9500 on the coral health and microbial community was far greater than oil alone, killing corals after only 4 days of exposure in the flow-through system. In the treatments with Corexit 9500, the action of the bioremediator consortium could not be observed directly because of the extreme toxicity of the dispersant to M. alcicornis and its associated microbiome.ConclusionsOur?results emphasize the importance of investigating the host-associated microbiome in order to detect and mitigate the effects of oil contamination on corals and the potential role of microbial mitigation and bioindicators as conservation tools. Chemical dispersants were far more damaging to corals and?their associated microbiome?than oil, and should not be used close to coral reefs. This study can aid in decision-making to minimize the negative effects of oil and dispersants on coral reefs. Video abstract. 2021-05-22T00:00:00Z Quantifying Real-Time Sample Temperature Under the Gas Environment in the Transmission Electron Microscope Using a Novel MEMS Heater. http://hdl.handle.net/10754/669231 Quantifying Real-Time Sample Temperature Under the Gas Environment in the Transmission Electron Microscope Using a Novel MEMS Heater. Li, Meng; Xie, De-Gang; Zhang, Xixiang; Yang, Judith C; Shan, Zhi-Wei Accurate control and measurement of real-time sample temperature are critical for the understanding and interpretation of the experimental results from in situ heating experiments inside environmental transmission electron microscope (ETEM). However, quantifying the real-time sample temperature remains a challenging task for commercial in situ TEM heating devices, especially under gas conditions. In this work, we developed a home-made micro-electrical-mechanical-system (MEMS) heater with unprecedented small temperature gradient and thermal drift, which not only enables the temperature evolution caused by gas injection to be measured in real-time but also makes the key heat dissipation path easier to model to theoretically understand and predict the temperature decrease. A new parameter termed as ¡°gas cooling ability (H)¡±, determined purely by the physical properties of the gas, can be used to compare and predict the gas-induced temperature decrease by different gases. Our findings can act as a reference for predicting the real temperature for in situ heating experiments without closed-loop temperature sensing capabilities in the gas environment, as well as all gas-related heating systems. 2021-05-21T00:00:00Z DNA-Binding and Cytotoxicity of Copper(I) Complexes Containing Functionalized Dipyridylphenazine Ligands http://hdl.handle.net/10754/669207 DNA-Binding and Cytotoxicity of Copper(I) Complexes Containing Functionalized Dipyridylphenazine Ligands Alsaedi, Sammar; Babgi, Bandar A.; Abdellatif, Magda H.; Arshad, Muhammad N.; Emwas, Abdul-Hamid M.; Jaremko, Mariusz; Humphrey, Mark G.; Asiri, Abdullah M.; Hussien, Mostafa A. A set of copper(I) coordination compounds with general formula [CuBr(PPh3)(dppz-R)] (dppz-R = dipyrido[3,2-a:2¡¯,3¡¯-c]phenazine (Cu-1), 11-nitrodipyrido[3,2-a:2¡¯,3¡¯-c]phenazine (Cu-2), 11-cyanodipyrido[3,2-a:2¡¯,3¡¯-c]phenazine (Cu-3), dipyrido[3,2-a:2¡¯,3¡¯-c]phenazine-11-phenone (Cu-4), 11,12-dimethyldipyrido[3,2-a:2¡¯,3¡¯-c]phenazine (Cu-5)) have been prepared and characterized by elemental analysis, 1H-NMR and 31P-NMR spectroscopies as well as mass spectrometry. The structure of Cu-1 was confirmed by X-ray crystallography. The effect of incorporating different functional groups on the dppz ligand on the binding into CT-DNA was evaluated by absorption spectroscopy, fluorescence quenching of EtBr-DNA adducts, and viscosity measurements. The functional groups affected the binding modes and hence the strength of binding affinities, as suggested by the changes in the relative viscosity. The differences in the quenching constants (Ksv) obtained from the fluorescence quenching assay highlight the importance of the functional groups in altering the binding sites on the DNA. The molecular docking data support the DNA-binding studies, with the sites and mode of interactions against B-DNA changing with the different functional groups. Evaluation of the anticancer activities of the five copper compounds against two different cancer cell lines (M-14 and MCF-7) indicated the importance of the functional groups on the dppz ligand on the anticancer activities. Among the five copper complexes, the cyano-containing complex (Cu-3) has the best anticancer activities. 2021-05-20T00:00:00Z HoMEmenuCopyrights 2015.All rights reserved.More welcome - Collect from power by english Blok number sss85786789633111 Copyright